coding

variant和gene expression是生物信息中两个非常重要的核心站点（根据中心法则，还有表观、3D genome、isoform、蛋白），这也是两个最能被准确测量的维度，在Post-GWAS，它们两的关系是我们研究的重点。 显然variant主要分为两类： coding noncoding 这两大类的分析方法截然不同，coding主要直接影响了mRNA和蛋白；而noncoding，我们主要认知都是在调控上。 先看看文献（搜 coding variant and gene expression ）： The Post-GWAS Era: From Association to Function Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk The influence of genetic variation on gene expression The impact of rare variation on gene expression across tissues 马上深入探索~ 来源： https://www.cnblogs.com/leezx/p/11779620.html

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 问题: I try send request like http://site.com/abc%2Fabc and it doesn't work (send status 400). How I understand tomcat doesn't accept encoded path separators for security reasons, but I don't know how to enable this coding. (I have found only option AllowEncodedSlashes for apache http server). Can you help me? UPDATE I fixed this trouble using tiny hack - before render replace all '/' characters on '|' and after reverse this characters on '/' 回答1: There is a Tomcat option to allow encoded path separators. Set the CATALINA_OPTS env var to -Dorg

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 问题: I need to use different dynamic library over a execution cycle of a program. Looking at dlfcn.h I thought this was possible. I confess of not reading much literature on dynamic library loading. OK here is what I do - I have created shared library called `libdynamicTest.so.1` The main APP opens this solib ( dlopen ), gets the function pointer ( dlsym ), run it and then close it back ( dlclose ) Everything is fine until here. Now suppose I replace my libdynamicTest.so.1 by another libdynamicTest.so.1 (some code diff) I see a Segmentation fault

在使用layui的form表单做验证提交的时候，如果结合vue，或者是三级联动的时候，就需要做事件监听了。 具体语法： form.on('event(过滤器值)', callback); 可以用于监听：select，checkbox，switch，radio，submit 的改变 1）：监听select的改变 <!-- 不用form 用div也可以 --> <form class="layui-form"> <div class="layui-form-item"> <label class="layui-form-label">下拉选择框</label> <div class="layui-input-block"> <select name="interest" lay-filter="aihao"> <option value="0">写作</option> <option value="1">阅读</option> <option value="2">听歌</option> <option value="4">游戏</option> </select> </div> </div> </form> <script type="text/javascript" src="./layui/layui.js"></script> <script type="text

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 问题: Are there are any performance cost by creating, throwing and catching exceptions in Java? I am planing to add 'exception driven development' into a larger project. I would like to design my own exceptions and include them into my methods, forcing developers to catch and do appropriate work. For example, if you have a method to get a user from the database based on a name. public User getUser(String name); However, it is possible that the user might be null and it is common to forget to check this before using a User's public method. User

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 问题: Is there a way to spawn an interactive python console (preferably iPython) during program execution without pausing main program and be able to check and modify program variables? Something similar to what browsers offer for JavaScript. I know about pdb.set_trace() and IPython.embed() , but both of them pause program execution and require to place them somewhere in source code of the program. This would be extremaly useful for desktop game development in python. 回答1: You could roll-your-own somewhat with threading : #!/usr/bin/python3 def

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 问题: i want to get value of Column A of excel sheet1 into some variable of visual basic and then after changing this value then send back to next sheet2 回答1: This is a complete and working project example that will copy the value from Sheet1, Cell A1 to Sheet2, Cell A1: ' declare these variables & you need to add a reference ' to the microsoft excel 'xx' object library. ' you need two command buttons: cmdCopy and cmdSave ' on the form, an excel file in c:\book1.xls Dim xl As New Excel.Application Dim xlsheet As Excel.Worksheet Dim xlwbook As

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 问题: I want to invoke a browser (e.g. Internet Explorer/Firefox/Google Chrome/Opera) via a Java interface. Also I need to pass some web links to this Java process. How to achieve this? 回答1: You can use the desktop API : java.awt.Desktop.getDesktop().browse(new URI("http://stackoverflow.com")); This would launch a browser 回答2: You can do that with Desktop#browse() . It would however only launch the system default configured browser. 回答3: See Using the Desktop API in Java SE 6 " Opening the Browser " 回答4: You can run the browser executable as a

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 由 翻译 强力驱动 问题: I have two buttons in my program and i want that when i press first button the second button is clicked automatically ( in the event handler of first button , i want to press the second button through coding). private void button1_Click ( object sender , EventArgs e ) { passWord = pwd . Text ; user = uName . Text ; loginbackend obj = new loginbackend (); bool isValid = obj . IsValidateCredentials ( user , passWord , domain ); if ( isValid ) { loginbackend login = new loginbackend (); passWord = pwd . Text ; login . SaveUserPass (

可以将文章内容翻译成中文,广告屏蔽插件可能会导致该功能失效(如失效，请关闭广告屏蔽插件后再试): 问题: My assignment asks me to access a test.txt document, so the file name has to be hard coded to my C drive. I have no idea what hardcoding means. Can somebody please help me with this? 回答1: "hard coding" means putting something into your source code. If you are not hard coding, then you do something like prompting the user for the data, or allow the user to put the data on the command line, or something like that. So, to hard code the location of the file as being on the C: drive, you would just put the pathname of the file all together in