I need to add my application to the startup and hence, need to set the Registry Key with the Installation path. I have got this working through the Visual Studio Setup project but can't figure out how to do it through a ClickOnce deployment.
Anyone know how to set registry keys when using ClickOnce for installation?
ClickOnce can't do this. If you want your app to start when the user logs in, you have to write code in your application to do it (copy a shortcut to the startup folder, edit the registry, etc.)
Also, keep in mind that if you write code to handle this scenario, it won't be undone when the user uninstalls your application.
Here is a forum question and blog post that should help you out. And here are similar SO questions, 401816 and 1650650.
来源：https://stackoverflow.com/questions/1763611/set-registry-key-through-clickonce-installation