/home/yueyao/bio/anaconda2/bin/java -jar /home/yueyao/bio/anaconda2/share/picard-2.14.1-0/picard.jar MarkDuplicates I=/home/yueyao/11.BSA/outdir/04.preresult/L-pool/A10/L-pool.A10.sort.rg.bam O=/home/yueyao/11.BSA/outdir/04.preresult/L-pool/A10/L-pool.A10.mark.dup.bam M=/home/yueyao/11.BSA/outdir/04.preresult/L-pool/A10/L-pool.A10.mark.dup.metrics VALIDATION_STRINGENCY=SILENT
解决办法
/home/yueyao/bio/anaconda2/bin/java -jar /home/yueyao/bio/anaconda2/share/picard-2.14.1-0/picard.jar MarkDuplicates I=/home/yueyao/11.BSA/outdir/04.preresult/L-pool/A10/L-pool.A10.sort.rg.bam O=/home/yueyao/11.BSA/outdir/04.preresult/L-pool/A10/L-pool.A10.mark.dup.bam M=/home/yueyao/11.BSA/outdir/04.preresult/L-pool/A10/L-pool.A10.mark.dup.metrics VALIDATION_STRINGENCY=SILENT MAX_RECORDS_IN_RAM=1000000 MAX_FILE_HANDLES_FOR_READ_ENDS_MAP=1000
来源：https://www.cnblogs.com/raisok/p/10917766.html