I am encountering a problem with Android ADB debugging through USB.
Using Macbook Air 2013 and trying to connect Nexus 6 dev phone.
On the MAC Android Studio, android latest sdk is installed.
When I do
adb kill-server
adb devices
I get:
adb I 661 9881 usb_osx.cpp:259] Found vid=18d1 pid=**** serial=*****
adb I 661 9881 usb_osx.cpp:259]
adb E 661 9881 usb_osx.cpp:331] Could not open interface: e00002c5
adb E 661 9881 usb_osx.cpp:265] Could not find device interface
So it found the device, vendor id, product id and serial match what I find in the system information for the Nexus 6.
Following suggestions found online I tried - but no success - the following to resolve:
dis- and reenabling debugging mode on the phone, also switching between USB configs for charging, MTP, PTP, RNDIS, Audio Source, MIDI, always making sure the authoriztation for the Mac's RSA fingerprint is given
closing Android Studio / DDMS, killing adb through 'kill-server' command as well as killing process through Apple activity monitor
run adb as root
reboot the Mac several times
reboot the Nexus 6
reinstall Android SDK completely
tried with another debugging enabled Android Device (Samsung Galaxy Tab, also here adb found correct device info but cannot access interface with same error)
tried with 3 different USB cables, all cables which were originally shipped with Android devices
Through google I learned that error code e00002c5 means the device is already in use by another driver.
I had recently installed Sophos Home Antivir. Thinking that this might prevent ADB from opening the device interface, I uninstalled Sophos completely with the provided uninstaller and rebooted the Mac.
Any hint is appreciated:
which steps to resolve?
as e00002c5 seems to be a clear indicator that another driver has the device in use, how to find out which process that is and how to stop it from doing that
I ran into this error as well, and it turned out that the problem for me was that a Stetho tab was open in Chrome (i.e. a tab at URL chrome://inspect/#devices ), which I guess was causing the device to be in use. Closing that tab, then running adb kill-server, made adb devices work again.
Same symptoms with a Galaxy S7 attached to Mac via USB. In my case, I had the Tizen IDE for Samsung Gear Development open. That also prevented adb working properly. Closing the Tizen IDE immediately helped.
In case you connect the mobile phone the first time, you may already have acknowledged the authorization for the computer on the phone. You have to delete the authorization on the phone and re-connect / re-auth it. Otherwise, the device will show in the device list, but is unauthorized. (I.e. you can't debug...)
If you are using VirtualBox and have a virtual machine opened, you are probably trying to use adb from your host while it is plugged on your virtual machine. The problem is that you cannot have your device plugged on both at the same time.
Solution : Uncheck your device on the bottom right panel if it is detected by your Virtual Machine.
If you have been accessing your device on virtual box and now trying to access it from your host OS, first you have to disconnect your device from the virtual box. To do that go to setting> USB > unchecked the device from list
Then unplug your phone first and replug it. Or kill and start the server using
>adb kill-server>adb start-server. It works for me.
I encountered this issue with the message "Could not open interface: e00002c5". e00002c5 indicates that another app is using the device. Tizen studio was the app causing this issue. Closed Tizen IDE and connected devices were available in the adb devices list.
I was debugging my Mobillyo app with a LG K4 phone. I closed Android Studio then enabled USB Debugging in the phone settings,left the settings open, reopened Android Studio did RUN, a dialog opend with the phone info and Unauthorized, was asked to approve on the phone, touched Ok and it worked.
来源：https://stackoverflow.com/questions/35650024/macbook-adb-cannot-open-interface