I don't know what I've switched on (by accident) but every time I have the Inspect Element area open and then try to click anything on the webpage not within the Inspect Element area (especially something jQuery related like a slideshow for example) it greys the page, shows a message saying 'Paused in debugger' and then opens a jQuery file within the Sources section of Inspect Element.
Within the 'Call Stack' area, it shows a message saying 'Paused on a "click" Event Listener'.
I don't remember switching this feature on but I'm keen for it to be switched off.
I know this question has been asked before - I thought I'd found the answer when everyone suggested we look to see if the 'Pause' option is switched on (blue). However, it's not switched on, it's grey not blue or any other colour and when I hover over it, it says "Don't pause on exceptions. Click to Pause on all exceptions".
You might also check the Source tab, check under the Event Listener Breakpoints panel if you've set any breakpoints under 'Mouse'.
Found solution here, if the little octagonal stop/pause sign (at lower left of Chrome "Sources") is colored (blue or purple), you need to click on it until it's black again.
This can also cause the issue
Break Point icon at top left should be blue like this(For Deactivate BreakPoints)
Should not grey like this
It did drive me nuts for a short while.....scroll all the way to the bottom
of breakpoint window and you'll find XHR Breakpoints & under it there is the Any XHR checkbox...
Go to Elements tab and remove all breakpoints from right pane under DOM Breakpoints
Goto the sources tab and check all breakpoints.
One possible cause, it that you've enabled the "pause on exceptions" (the little stop-sign shaped icon with the pause (||) symbol with in in the lower left of the window). Try clicking that back to the off/grey state (not red nor blue states) and reload the page.
来源：https://stackoverflow.com/questions/13013639/chrome-paused-in-debugger-issue