One way is to calculate their gcd and check if it is 1.
Is there some faster way?
The Euclidean algorithm (computes gcd) is very fast. When two numbers are drawn uniformly at random from [1, n], the average number of steps to compute their gcd is O(log n). The average computation time required for each step is quadratic in the number of digits.
There are alternatives that perform somewhat better (i.e., each step is subquadratic in the number of digits), but they are only effective on very large integers. See, for example, On Schönhage's algorithm and subquadratic integer gcd computation.
if you're running on a machine for which division/remainder is significantly more expensive than shifts, consider binary GCD.
来源：https://stackoverflow.com/questions/1483404/what-is-the-fastest-way-to-check-if-two-given-numbers-are-coprime