I am new to both Pyramid and SQLAlchemy. I am working on a Python Pyramid project with SQLAlchemy. I have a simple model set up below. How would I go about being able to use
I think you need a different model for each schema. __abstract__ can make this less painful.  This follows on to Paul Yin's answer...
Define an __abstract__ LoadTender model, so you don't have to keep coding it.
#base.py
class LoadTender(Base):
    __abstract__ = True
    id = ...
    def __repr__ ...
Put a schema-specific Base in the hierarchy for each schema.
#schema1.py
from base import LoadTender
PublicBase = declarative_base(metadata=MetaData(schema='public'))
class LoadTender(PublicBase, LoadTender):
    __tablename__ = 'load_tenders'
Do the same for other schema.
just a guess
LoadTender.__table_args__["schema"] = "whatever"
Probably best to put it somewhere where your app configurator is creating the app
You can have a base module in package model
app\
    models\
        base.py
        schema1.py
        schema2.py
    views\
    ...
declare Base in base.py, then import it to other schemas