Sample Text
1234 Main St Smallville, KS 92348Small County
Should yield:
1234 Main St Smallville, KS 92348
Sa
Find the last digit in the string and then remove all the characters after it with re.sub:
import re
address = "1234 Main St Smallville, KS 92348Small County "
address = re.sub(r'(\d)\D+$', r'\1', address)
print(address) # => 1234 Main St Smallville, KS 92348
See the IDEONE demo
The regex matches and captures into Group 1 a digit (with (\d)) and then matches one or more characters other than a digit (\D+) up to the end of the string ($). The replacement pattern is a mere \1, a backreference to the digit we captured with Group 1 (to restore it in the resulting string).
You can use greedy .* before \d+ to make sure to match upto last digits:
>>> print re.findall(r'^(.*\d+).*$', address)[0]
1234 Main St Smallville, KS 92348
Regex Demo