I am trying to have two inter-depedent x-axis in a matplotlib imshow() plot. I have bottom x-axis as the radius squared and I want the top as just the radius. I have tried s
You're misunderstanding what twiny does. It makes a completely independent x-axis with a shared y-axis.
What you want to do is have a different formatter with a linked axis (i.e. sharing the axis limits but nothing else).
The simple way to do this is to manually set the axis limits for the twinned axis:
import numpy as np
import matplotlib.pyplot as plt
from matplotlib.ticker import FuncFormatter
fig, ax1 = plt.subplots()
ax1.plot(range(10))
ax2 = ax1.twiny()
formatter = FuncFormatter(lambda x, pos: '{:0.2f}'.format(np.sqrt(x)))
ax2.xaxis.set_major_formatter(formatter)
ax2.set_xlim(ax1.get_xlim())
plt.show()

However, as soon as you zoom or interact with the plot, you'll notice that the axes are unlinked.
You could add an axes in the same position with both shared x and y axes, but then the tick formatters are shared, as well.
Therefore, the easiest way to do this is using a parasite axes.
As a quick example:
import numpy as np
import matplotlib.pyplot as plt
from matplotlib.ticker import FuncFormatter
from mpl_toolkits.axes_grid1.parasite_axes import SubplotHost
fig = plt.figure()
ax1 = SubplotHost(fig, 1,1,1)
fig.add_subplot(ax1)
ax2 = ax1.twin()
ax1.plot(range(10))
formatter = FuncFormatter(lambda x, pos: '{:0.2f}'.format(np.sqrt(x)))
ax2.xaxis.set_major_formatter(formatter)
plt.show()
Both this and the previous plot will look identical at first. The difference will become apparent when you interact (e.g. zoom/pan) with the plot.