Is there any difference in performance between the operator IS NULL and the function ISNULL()?
Looking into the MySQL manual, they seem to be synonyms really.
MySQL manual on IS NULL
MySQL manual on ISNULL()
and even if they aren't, I would tend to trust the query optimizer to pick the best solution.
This thread is similar, though not exactly on MySQL. According to the test shown there:
IS NULL is more efficient as it doesn't require a scan.
Seek is generally faster than a scan as it only includes qualifying records, while scan includes every row. It is explained in more detail here.
Another difference (though it's not performance) is their negation syntax:
IS NOT NULL /* using NOT operator */
! ISNULL() /* using exclamation mark */