Once you're logged in...
WHO will tell you where you are.
LISTF will tell you the files/tables available.
LIST filename will get you at least the keys.
LIST DICT filename will give you some metadata.
HELP will give you some general info.
HELP LIST might get you on your way.
Brian Leach, a UniVerse Consultant in the UK, has some excellent self-paced learning material
The U2-Users mailing list has a tremendous depth of knowledge.