Use filter_input if possible (php5 +) It keeps it a lot cleaner and as far as im aware you can sanitise and validate everything you could need using it.
You can use filter var array and for example FILTER_SANITIZE_STRING flag to filter the whole post array
filter_var_array($_POST, FILTER_SANITIZE_STRING) //just an example filter
There are loads of different filter options available on the w3schools filter reference