I installed the updates from http://support.microsoft.com/kb/2468871 in Windows 2008 R2. Planning to install it on Windows 2003 R2 SP2. The update was installed without much delay and it worked without a restart.
It replaces
2183292
(http://support.microsoft.com/kb/2183292/ )
FIX: "Failure sending mail" error message when you send an email message by using a .NET Framework 4-based application that uses the "System.Net.Mail.SmtpClient" class if the email attachment is larger than 3 MB
2413613
(http://support.microsoft.com/kb/2413613/ )
A shortcut menu may appear far away from the mouse pointer when you run a Windows Presentation Foundation application that is based on the .NET Framework 4
2298853
(http://support.microsoft.com/kb/2298853/ )
FIX: Visual Studio 2010 error: "Error 1 error MSB4014: The build stopped unexpectedly because of an internal failure"
2461678
(http://support.microsoft.com/kb/2461678/ )
A .NET Framework 4-based WPF application crashes if the source object of a data binding in a control is an element that is defined outside the name scope of the control
2484841
(http://support.microsoft.com/kb/2484841/[anySimpleType]/ )
FIX: A .NET Framework 4.0-based WPF application may stop responding if you right-click a control to open a pop-up control
Hope this helps.
Thanks,
Raghav