Personally, the signal:noise ratio in e-mail is getting to the point that I'm far more likely to respond to the little tag in my (U.S.) mailbox that says "Signature Required for proof of delivery" than I am to yet another e-mail with a subject of "YOU MUST READ THSI IMPORTANT MESSAGE NOW!!!1". As a matter of fact, that e-mail would probably land straight in my potential spam bucket, to be reviewed sometime during the next ice age.
Additionally, SMTP is still pretty much "best effort"; there are no guarantees that a time-sensitive, life-saving e-mail will arrive on time... Or at all.
If these messages are mission-critical, I would seriously re-consider your approach.