I\'m creating some tool what performs several operations like NUnit. Inside this tool I open .dll assembly and invoke methods form it to run some test.
Everything
The CLR does support loading multiple versions of strongly named assemblies into the same AppDomain. This only works though if your assemblies are strongly named and each one has a different version than the other.
I'm guessing it's more likely that you are dealing with unsigned assemblies. If that is the case then what you're asking for isn't really possible. Once a given assembly is loaded into an AppDomain it will remain there until the AppDomain is unloaded. To get this to work you will have to abstract out all of the work around the loaded assemblies into a separate AppDomain and use a new AppDomain for every assembly
Try like this:
string dllFile = "C:\\sample.dll";
Assembly asmLoader = Assembly.LoadFile(dllFile);
Type[] types = asmLoader.GetTypes();
Since all resources from the assembly cannot be reloaded/replaced it's assembly resources while application is still running. It will only be replaced/removed when application is unloaded or the that Assembly that holds it.
Use LoadFile() method. Hope it helps.
To expand on JaredPar's answer, you will need to create a new AppDomain and use Remoting to communicate between the two.
Check out http://msdn.microsoft.com/en-us/library/kwdt6w2k(v=vs.85).aspx to help get you started.