I spent a bout 4 hours on having a simple transition with an acceptable performance:
First I tried this code :
left: 2000px;
-webkit-transition: left
As the result my 4 hours experiments it is better to use transform like below:
-webkit-transform: translate(2000px, 0);
-webkit-transition: -webkit-transform 1s linear;
-moz-transform: translate(2000px, 0);
-moz-transition: -moz-transform 1s linear;
-ms-transform: translate(2000px, 0);
-ms-transition: -ms-transform 1s linear;
This was great on IE10, Chrome v21.0.1180.89 and FireFox v15.0.1.
Note: IE9 does not support tarnsforms
Don't use left or top, bottom, margin or padding properties to move elements, but only "transform: translate".
In the same way, to resize elements use only "transform: scale" instead of height or width.
Left, top, bottom, margin, padding, height, width properties (and many others) force the browser to recalculate all the layout, so geometry of many elements, with a lot of CPU work.
Each property has a different weight, in this article it's clearly explained high performance animations
Edit1: triggers.com seems to be a good page if you don't remember each property weight