LaTeX? Seriously? I wasn't aware anyone outside academia still used it. I'd go with HTML, which you can save as PDF from the web browser. If you really must have some advanced typographic stuff, go with Word instead - it has a way to save to HTML (probably not as clean as one would like), and you can save as PDF with a free plug-in (downloadable separately).
Oh, and I wouldn't bother using things like InDesign - they are overkill. Also, don't bother paying for Acrobat Professional - there is a zillion free solutions available.