We were facing this problem in an academic project that involved Eclipse software, and we used plastex to convert Latex to HTML and Eclipse Help. Getting it to work was quite difficult, but the end result looks really nice. You can see all three versions here:
http://handbook.event-b.org/
Further, as this is an open project, the code (build scripts) are available. We have a continuous build system (Jenkins) that rebuilds everything when new Latex is checked in. This is particularly nice, as contributors don't need to install the toolchain on their systems. They just check in the new Latex and check on the server whether the HTML was produced correctly. Sources:
http://sourceforge.net/p/rodin-b-sharp/svn/HEAD/tree/trunk/Handbook/org.rodinp.handbook.feature/
Best, Michael