Must know:
1) C (system programming, understanding of machine architecture)
2) Perl or Python or Ruby (practical day-to-day tasks)
3) Java or C# or C++ (OOP, and quite important to get a job these days)
Really important:
1) Haskell or ML (functional programming; changes the way you think)
2) Lisp or Scheme (power of macros)
Nice additionals:
1) Forth (very low-level, explicit stack operation + joy to write your own interpreter)
2) Assembly languages (know how your CPU works)
3) Erlang (parallel processing)
4) Prolog (logic programming)
5) Smalltalk (true OOP and true interactive developent)