It depends on the nature of your application. And, since you did not describe it in great detail, it is an impossible question to answer. I find Backbone to be the easiest, but I work in Angular all day. Performance is more up to the coder than the framework, in my opinion.
Are you doing heavy DOM manipulation? I would use jQuery and Backbone.
Very data driven app? Angular with its nice data binding.
Game programming? None - direct to canvas; maybe a game engine.
