Theory says that highly cohesive, loosely coupled implementations are the way forward.
So I suppose you are questioning that approach, namely separating concerns.
Should my aspx.cs file be interacting with the database, calling a sproc, and understanding IDataReader?
In a team environment, especially where you have less technical people dealing with the aspx portion of the application, I don't need these people being able to "touch" this stuff.
Separating my domain from my database protects me from structural changes in the database, surely a good thing? Sure database efficacy is absolutely important, so let someone who is most excellent at that stuff deal with that stuff, in one place, with as little impact on the rest of the system as possible.
Unless I am misunderstanding your approach, one structural change in the database could have a large impact area with the surface of your application. I see that this separation of concerns enables me and my team to minimise this. Also any new member of the team should understand this approach better.
Also, your approach seems to advocate the business logic of your application to reside in your database? This feels wrong to me, SQL is really good at querying data, and not, imho, expressing business logic.
Interesting thought though, although it feels one step away from SQL in the aspx, which from my bad old unstructured asp days, fills me with dread.