I am currently using the Anaconda python distribution for my project (NOT the anaconda plugin, they have the same name, but the one I am using includes Numpy, IPython, etc.
You can get it working by distinguishing the name of python.
For example change
C:\Python27\python.exe
to
C:\Python27\python2.exe
Change your environment variables to reference this change. Type python2 in cmd to confirm its working.
And then you should be able to reference this from your build hotkey.
{
"path": "/home/username/anaconda/bin",
"cmd": ["python2", "-u", "$file"],
"file_regex": "^[ ]*File \"(...*?)\", line ([0-9]*)",
"selector": "source.python"
}