Glimmer is an interesting option for JRuby users which provides a very Ruby-ish interface to the SWT toolkit. (SWT is the user interface framework behind Eclipse, which delivers fast performance and familiar UI metaphors by making use of native widgets on the various platforms it supports: Windows, OS X, Linux, etc.) SWT always appealed to me as a Java developer, but coding it was painful in the extreme. Glimmer makes the process a lot more straightforward by emphasizing convention over configuration, and by valuing DRYness and all the other normal Ruby goodness.
Another neat option is SproutCore, a Javascript-based GUI toolkit with Ruby bindings developed by Apple. At least, the demos for it look great, and otherinbox built a pretty slick looking application on top of it. Personally, I've spent quite a few hours trying to get it running on two systems -- one Windows and one Linux -- and haven't succeeded on either one -- I keep running into dependency issues with Merb or other pieces of the SproutCore stack. But it's intriguing enough that I'll go back after a few weeks and try again, hoping that the issues get resolved in that time.