We can take the origins of x
back much further, of course :-) François Viète (1540-1603) produced a book titled In artem
analyticem isagoge (“Introduction to
the Analytic Art”), which was the first work that systematically used letters to represent numbers.
Edit: Porges, below, points me to the really cool A History of Mathematical Notations by Cajori. To my pleasant surprise, the entire work is available online: http://archive.org/details/historyofmathema031756mbp