If you are relying on the client to send the final score to the server, then there is no way (afaik) to prevent a genius from cheating. But I think you might be able to prevent stupid people (and honest people) from cheating, so that only geniuses and their friends will dominate your leaderboards.
There are two ways I can think of
1.) "security through obscurity."
Come up with an algorithm that transforms simple scores into something else (and to transform them back). Then obfuscate it. Complicate it. Write a function that multiplies it by q and divides it by ralph. Apply a bunch of functions to it, and among the 5-15 functions that do random stuff to it, include one that multiplies the number by 19 ( a prime number ). On your server, check to make sure every incoming number (or letter) is divisible by 19, and decode
You have to write a bunch of complex code that transforms simple scores into something crazy-looking. You have to write a series of functions in the least-efficient, most spaghetti-code fashion possible. Use
One thing you cold do is to have a set of disallowed values. I.e., perhaps all points awarded are even. If anyone tries to submit an odd number, they are obviously cheating (and very stupid).
2.) time
You should be able to know when the user started the game. You should have a session started and record when they requested the page. Then you should also be able to tell when they submitted their score. And you should also know what the time series is for max points. I.e. can you get 5 points per minute, 100 per minute, minute^3, etc... If user submits more points than are possible during that time, they are cheating.
You could also strike a balance between server and client processing and make the client should send progress update every x minutes by ajax. And if it fails to report, you assume it's been compromised (much like in Bond movies, when he's infiltrating the enemy's lair and he snaps some guard's neck. When the guard doesn't respond to his next 10-minutely check-in, the alarms will go off).
If you've ever played Zynga Poker, you've probably seen what happens when someone at the table has a slow internet connection.