I disagree with the accepted answer being "the easiest", particularly if you want to use virtualenv.
You can use the Unofficial Windows Binaries instead. Download the appropriate wheel from there, and install it with pip
:
pip install pywin32-219-cp27-none-win32.whl
(Make sure you pick the one for the right version and bitness of Python).
You might be able to get the URL and install it via pip
without downloading it first, but they're made it a bit harder to just grab the URL. Probably better to download it and host it somewhere yourself.