A lot of people claim HTML5 will kill off plugins like Flash and Silverlight, but that simply isn't the case.
Take for instance, this scenario.
Load a binary file over a url. For the sake of the demo, we'll use shapefile format (.shp), which contains geographical polygons in a coordinate system.
Parse the byte contents client side.
Draw the contents in an efficient manner.
Demo: http://www.libertyvanguard.com/liberty-gis
This is just one example where plugin technology won't be replace by HTML5.