Suppose you have a dictionary like:
{\'a\': 1,
 \'c\': {\'a\': 2,
       \'b\': {\'x\': 5,
             \'y\' : 10}},
 \'d\': [1, 2, 3]}
Ho
I tried some of the solutions on this page - though not all - but those I tried failed to handle the nested list of dict.
Consider a dict like this:
d = {
        'owner': {
            'name': {'first_name': 'Steven', 'last_name': 'Smith'},
            'lottery_nums': [1, 2, 3, 'four', '11', None],
            'address': {},
            'tuple': (1, 2, 'three'),
            'tuple_with_dict': (1, 2, 'three', {'is_valid': False}),
            'set': {1, 2, 3, 4, 'five'},
            'children': [
                {'name': {'first_name': 'Jessica',
                          'last_name': 'Smith', },
                 'children': []
                 },
                {'name': {'first_name': 'George',
                          'last_name': 'Smith'},
                 'children': []
                 }
            ]
        }
    }
Here's my makeshift solution:
def flatten_dict(input_node: dict, key_: str = '', output_dict: dict = {}):
    if isinstance(input_node, dict):
        for key, val in input_node.items():
            new_key = f"{key_}.{key}" if key_ else f"{key}"
            flatten_dict(val, new_key, output_dict)
    elif isinstance(input_node, list):
        for idx, item in enumerate(input_node):
            flatten_dict(item, f"{key_}.{idx}", output_dict)
    else:
        output_dict[key_] = input_node
    return output_dict
which produces:
{
  owner.name.first_name: Steven,
  owner.name.last_name: Smith,
  owner.lottery_nums.0: 1,
  owner.lottery_nums.1: 2,
  owner.lottery_nums.2: 3,
  owner.lottery_nums.3: four,
  owner.lottery_nums.4: 11,
  owner.lottery_nums.5: None,
  owner.tuple: (1, 2, 'three'),
  owner.tuple_with_dict: (1, 2, 'three', {'is_valid': False}),
  owner.set: {1, 2, 3, 4, 'five'},
  owner.children.0.name.first_name: Jessica,
  owner.children.0.name.last_name: Smith,
  owner.children.1.name.first_name: George,
  owner.children.1.name.last_name: Smith,
}
A makeshift solution and it's not perfect.
NOTE: 
it doesn't keep empty dicts such as the address: {} k/v pair.
it won't flatten dicts in nested tuples - though it would be easy to add using the fact that python tuples act similar to lists.
Or if you are already using pandas, You can do it with json_normalize() like so:
import pandas as pd
d = {'a': 1,
     'c': {'a': 2, 'b': {'x': 5, 'y' : 10}},
     'd': [1, 2, 3]}
df = pd.io.json.json_normalize(d, sep='_')
print(df.to_dict(orient='records')[0])
Output:
{'a': 1, 'c_a': 2, 'c_b_x': 5, 'c_b_y': 10, 'd': [1, 2, 3]}
Not exactly what the OP asked, but lots of folks are coming here looking for ways to flatten real-world nested JSON data which can have nested key-value json objects and arrays and json objects inside the arrays and so on. JSON doesn't include tuples, so we don't have to fret over those.
I found an implementation of the list-inclusion comment by @roneo to the answer posted by @Imran :
https://github.com/ScriptSmith/socialreaper/blob/master/socialreaper/tools.py#L8
import collections
def flatten(dictionary, parent_key=False, separator='.'):
    """
    Turn a nested dictionary into a flattened dictionary
    :param dictionary: The dictionary to flatten
    :param parent_key: The string to prepend to dictionary's keys
    :param separator: The string used to separate flattened keys
    :return: A flattened dictionary
    """
    items = []
    for key, value in dictionary.items():
        new_key = str(parent_key) + separator + key if parent_key else key
        if isinstance(value, collections.MutableMapping):
            items.extend(flatten(value, new_key, separator).items())
        elif isinstance(value, list):
            for k, v in enumerate(value):
                items.extend(flatten({str(k): v}, new_key).items())
        else:
            items.append((new_key, value))
    return dict(items)
Test it:
flatten({'a': 1, 'c': {'a': 2, 'b': {'x': 5, 'y' : 10}}, 'd': [1, 2, 3] })
>> {'a': 1, 'c.a': 2, 'c.b.x': 5, 'c.b.y': 10, 'd.0': 1, 'd.1': 2, 'd.2': 3}
Annd that does the job I need done: I throw any complicated json at this and it flattens it out for me.
All credits to https://github.com/ScriptSmith .
I always prefer access dict objects via .items(), so for flattening dicts I use the following recursive generator flat_items(d). If you like to have dict again, simply wrap it like this: flat = dict(flat_items(d))
def flat_items(d, key_separator='.'):
    """
    Flattens the dictionary containing other dictionaries like here: https://stackoverflow.com/questions/6027558/flatten-nested-python-dictionaries-compressing-keys
    >>> example = {'a': 1, 'c': {'a': 2, 'b': {'x': 5, 'y' : 10}}, 'd': [1, 2, 3]}
    >>> flat = dict(flat_items(example, key_separator='_'))
    >>> assert flat['c_b_y'] == 10
    """
    for k, v in d.items():
        if type(v) is dict:
            for k1, v1 in flat_items(v, key_separator=key_separator):
                yield key_separator.join((k, k1)), v1
        else:
            yield k, v