Given that I\'m not really bothered about backwards compatibility (I\'m exploring CSS3 and HTML5 based design, rather than relying on on graphics and such) what are the bene
It really depends on which features and which browsers you want to fully support. Even now some browsers are lagging.
Here is a really excellent guide: http://caniuse.com/
All browsers generally move towards standards support.
There are two issues
For these two reasons, we continue to use vendor-prefixed CSS rules in our stylesheets.
The only prefix you need right now is the -webkit for chrome and safari support. Webkit is needed for -webkit-animation, -webkit-font-feature-settings, display: -webkit-flex, -webkit-filter etc..
-ms, -o and -moz provide support for browsers that even their own companies have stopped supporting.