I have a ShellView using interactivity objects with prism\'s PopupWindowAction for show my custom settings view. And my ShellViewModel contain InteractionRequest object and
Probably you need to set the region manager manually, in the popup view's code behind (constructor), like this:
RegionManager.SetRegionName( theNameOfTheContentControlInsideThePopup, WellKnownRegionNames.DataFeedRegion );
RegionManager.SetRegionManager( theNameOfTheContentControlInsideThePopup, theRegionManagerInstanceFromUnity );
You'll have to assign a name to the content control hosting the region and somehow acquire the region manager (ServiceLocator.Current.GetInstance<IRegionManager>()).