WX has issues on the Mac.
I had a look here, as I want to get an event driven GUI API to do some stuff in Python. I have wx installed on my mac as part of MatPlotLib, but it does not work properly. It wont take in put from the keyboard. I have installed this three times on three different Mac operating systems, and though it worked the first time, the other two times I had this issue.
This version I am using with Enthought's distribution, so no installation was necessary. When I have installed it separately, there were so many dependent installations, that it was a trial to install.
From what I have read here, I will give Tkinter a go, as this needs to be simple and cross platform, but I thought I would just share the above with you. I like the Mac OS for a number of different reasons, but python tools install far easier on Windows (and probably other Linux). I just thought I would give a Mac perspective here.