I've been using TurboGears lately and absolutely love it. It competes with Django and Ruby On Rails for rapid development, but has a more flexible backend. That is, it's more of a collection of best-of-breed components that have been made to play well together than a single monolithic framework. You can easily swap out the object relational mapper if you need to, or replace the page templating language with something else without rewriting your entire application.
The real "where have you been all my life?" moment came when I spend about two minutes adding an AJAX autocomplete field to a form. I had to write a function to answer the AJAX requests and add a new field that called that function, and it worked perfectly the first time. I'd always wanted to play with AJAX but was a bit intimidated, and my first experience with it could not have been easier.
It has a 20 minute tutorial to make a functional wiki. Even if you don't think you'll be using it, read it or watch it and see how easy such a thing can be.
