I recently came across divascheme - an alternative set of key bindings for DrScheme. This is modal, and part of the justification is to do with RSI - specifically avoiding lots of wrist twisting to hit Ctrl-Alt-Shift-something. The coder has done an informal survey of fellow coders and found that emacs users suffered from more wrist pain than vi coders.
You can see him doing a short talk at LugRadio Live USA. (The video is a series of 5 minute talks and I can't remember how far through it is, sorry - if someone watches it and posts that here I'll edit this post to say when in the video it is).
Note I have not used divascheme.
