Speaking of pure performance, if you can run Java 6 you get about 1:1 performance when compared to optimized C++ (special cases notwithstanding, sometimes Java is faster, sometimes C++), the only problem you will have is of course stuff like database libraries, interconnectivity, scalability and such. I believe there's a variety of good to great solutions available to each of these problems but you won't find one language which would solve everything for you so I have to give you the age old advice: Choose the language you like and use that one.
Oh, you're still reading this? :) Well, here's some extra pointers.
- EVE Online uses Python for its client and server side code and it's both bug-ridden and laggy as something I don't think I should write here so that'd be an example of how Python can be extended to (poorly) serve vast amounts of users.
- While Java has some good to great solutions to various related problems, it's really not the best language out there for vast amount of users; it doesn't scale well to extremes without tuning. However there's multi-VM solutions to this which somewhat fix the issue, for example Terracotta is said to do the job well.
- While C++ is rather cumbersome, it allows for such a low-level interaction with the system that you may actually find yourself doing things you thought you couldn't do. I'm thinking of something like dynamic per-core microclustering of runtime code blocks for "filling" every possible clock cycle of the processor as efficiently as possible for maximum performance and things like that.
- Mono is far behind the .NET VM/equivalent on Windows platforms so you wouldn't be able to use the latest and fanciest features of C#. However Windows XP (x64) OEM licenses are so laughably cheap at the moment that with small investment you could get a bunch of those and you could then run your code on the platform it was meant to be. And don't fall into the Linux hype, Linux is your saviour only if you really know how to use it and especially XP is pretty damn fast and stable nowadays.