Background first: I have a database-first EF6 model in Visual Studio 2015 (latest nuget 6.1.3 pointing to a local SQL Server 2014 SP1 Express database) on a Windows 10 Pro lapto
We had the same issue on 2 laptops with Windows 10 and touchscreens. Killing the process TabTip.exe seems to solve the issue.
Source: https://connect.microsoft.com/VisualStudio/Feedback/Details/2011437
Go Task Manager and End Process on TabTip.exe (Touch Keyboard and Handwriting Panel). After doing that the designer will respond fine. Note if you click or touch the Keyboard icon in the TaskBar the TabTip.exe will re-start.