Since the vast majority of monitors are 16-bit color or more, including mobile devices, does it make sense to even consider web-safe colors when choosing color schemes? Or is i
IMHO the point is really moot. Colors that aren't web safe are dithered anyway. It may not look the best in 256-color modes but as long as functional elements of the page/applications are not dependent on those colors it will not disturb the user experience that much.
Also most users surfing in 256-color modes will be aware of the fact colors will be dithered as I don't think that a lot of sites adhere to the web-safe colorschemes anymore.