As well as I understand, MSYS2 is a fork of Cygwin with main goal to provide possibility to use MinGW-w64 packages. That goal is achieved at expense of total number of available software. Compare list of that of MSYS2 and Cygwin.
Essentially, that’s all. So while you did not need to compile something under MinGW-w64, you would hardly have any reason to use MSYS2 rather than original Cygwin.
