I just released Locomotive, which is an MVC framework inspired by Ruby on Rails.
Express is phenomenal, especially for smaller apps. Recognizing that, Locomotive is built completely on top of Express (similar to how Express builds on top of Connect). Locomotive essentially adds a controller layer along with a router that can declare resourceful routes and generates routing helper functions. Internally, everything is powered by Express, which means the view layer remains the same and all middleware can be reused.
One of the bigger hurdles when learning Node is figuring out how to best structure a web application. Locomotive attempts to solve that problem, using conventions from Ruby on Rails, while retaining the full power of Express and Node.