Assuming dates are in Column A:
=IF(OR(WEEKDAY($A1)=1,WEEKDAY($A1)=7),1,0)
Reads If the weekday is either Sunday or Saturday then True (Use Conditional Formatting)
Or you can modify the same formula so that the 'weekdays' starts on Monday so it looks like this:
=IF(WEEKDAY($A1,2)>5,1,0)