I\'m developing a vbnet/c#.NET based application that opens files with different applications(excel, word, etc).
The application is launched using Dim app As Proce
There are different approaches for this problem. You can calculate some sort of initial check-sum and see whether your document has any changes by redoing the check-sum and comparing against the original one.
This part is not very clear from your question, If the document gets saved, probably you can look at the date_modified value of the file to see whether there has been any modifications.