I have a list with two elements like this:
list_a = [27.666521, 85.437447]
and another list like this:
big_list = [[27.666519,
Assumptions:
This reads like a nearest neighbor search. Probably you should take into consideration a library dedicated for this, like scikits.ann.
Example:
import scikits.ann as ann
import numpy as np
k = ann.kdtree(np.array(big_list))
indices, distances = k.knn(list_a, 1)
This uses euclidean distance internally. You should make sure, that the distance measure you apply complies your idea of proximity.
You might also want to have a look on Quadtree, which is another data structure that you could apply to avoid the brute force minimum search through your entire list of lists.