My buddy wants to create a WordPress blog, but because he\'s picky about the design (specifically the fonts), he wants to use Flash for the frontend -- display, content creation
Flash can store and retreive information via HTTP easily enough, and I think Wordpress makes most things available via an XML-RPC interface, so you could write a Flash client that did all the display itself and just used the wordpress backend to save the data.
I'm not sure how this would, in any meaningful way, be "wordpress" though, rather than just a Flash based blog which used a tiny little bit of Wordpress's database.