We are having a problem deploying a reporting services report to a sql reporting services computer that is configured in SharePoint Integrated mode. I can successfully deploy to
I finally found the solution to this issue. Basically the build of sql server 2008 reporting services I installed added an RSWindowsNegotiate setting into rsreportserver.config file and I was running the reporting service under an account other than Network Service. I removed the RSWindowsNegotiate setting and just left the RSWindowsNTLM setting and everything started working properly for us.
More info can be found here, Solving the Reporting Services Login Issue