I understand that this doesn\'t take a significant chunk off of the entropy involved, and that even if a whole nother character of the GUID was reserved (for any purpose), w
Focusing on hexadecimal digits is confusing you.
A UUID is not made of hex. A UUID is made of 128 bits.
Humans would resent reading a series of 128 bits presented as a long string of 1 and 0 characters. So for the benefit of reading and writing by humans, we present the 128-bits in hex.
Always keep in mind that when you see the series of 36 hex characters with hyphens, you are not looking at a UUID. You are looking at some text generated to represent the 128-bits of that are actually in the UUID.
The first special meaning you mention, the “version” of UUID, is recorded using 4 bits. See section 4.1.3 of your linked spec.
The second special meaning you indicate is the “variant”. This value takes 1-3 bits. This See section 4.1.1 of your linked spec.
A hex character represents 4 bits (half an octet).
01 00 which in hex is 4 as it is too in decimal (base 10) numbers.10, for a decimal value of 2, as the variant. This pair of bits lands in the most significant bits of octet # 8. That octet looks like this, where ‘n’ means 0 or 1: 10 nn nn nn. A pair of hex characters represent each half of that octet. So your 17th hex digit, the first half of that 8th octet, 10 nn, can only have four possible values:
10 00 (hex 8) 10 01 (hex 9)10 10 (hex A)10 11 (hex B)