In my form there are two DropDownList controls.
1st is enabled and 2nd is disabled.
After selecting 1st dropdown I am changing selected value of 2nd dropdown
You would need to add another input that is hidden. Whenever you change the value of your 1st DropDownList, you'd change the value of your 2nd DropDownList AND the value of the hidden input.
Server-side, you're not looking at the value of the 2nd DropDownList, but at the value of your hidden input. Make sure the hidden value is always sync with the 2nd DDL when you post your form.