Does the HttpApplication class extended by Global.asax.cs exist for the lifetime of the application?
At what point can instances be created/destroyed?
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From the MSDN online page,
After all core application objects have been initialized, the application is started by creating an instance of the HttpApplication class. If the application has a Global.asax file, ASP.NET instead creates an instance of the Global.asax class that is derived from the HttpApplication class and uses the derived class to represent the application.
ASP.NET Application Life Cycle Overview