Inlining JavaScript function calls speeds up the execution and also reduces the code size after gzipping, as described in this article:
http://blog.calyptus.eu/seb/2
Let the JIT figure things like inlining out fr you. Inlining can easily worsen the performance by killing cache performance.
Also, unless you have identified the actual bottlenecks, doing premature optimization like this is hardly ever worth it.