Is there anyway to do a LINQ2SQL query doing something similar to this:
var result = source.GroupBy(a => new { a.Column1, a.Column2 });
You can pass StringComparer.InvariantCultureIgnoreCase to the GroupBy extension method.
var result = source.GroupBy(a => new { a.Column1, a.Column2 },
StringComparer.InvariantCultureIgnoreCase);
Or you can use ToUpperInvariant on each field as suggested by Hamlet Hakobyan on comment. I recommend ToUpperInvariant or ToUpper rather than ToLower or ToLowerInvariant because it is optimized for programmatic comparison purpose.