Does a System.Runtime.InteropServices.COMException of 0x80040154 always mean that the class isn\'t registered? I\'m getting a COMException which says \"Retrieving the COM c
There's an IBM technote that indicates that the Domino COM classes are not supported on a 64-bit OS. See https://www-304.ibm.com/support/docview.wss?uid=swg21454291 So it seems like even by compiling the code to run as x86 (as per mpownie's answer), you're still taking some chances.