What are peoples\' thoughts on the most performance efficient way to do the following query:
3 column table
if the combination of col_
Edit: Ignore my suggestions
You can use a composite key as ceejayoz said, however I think you need REPLACE INTO instead of UPDATE ON DUPLICATE KEY because REPLACE also inserts if no duplicate is found.
Note: I don't know the workings of UPDATE ON DUPLICATE KEY but it sounds like it doesn't perform inserts.